TY - JOUR AU - Stanulla, Martin AU - Schrauder, André AU - Welte, Karl AU - Schrappe, Martin PY - 2001 DA - 2001/04/10 TI - Tumor necrosis factor and lymphotoxin-alpha genetic polymorphisms and risk of relapse in childhood B-cell precursor acute lymphoblastic leukemia: a case-control study of patients treated with BFM therapy JO - BMC Hematology SP - 2 VL - 1 IS - 1 AB - Circulating levels of tumor necrosis factor (TNF) and lymphotoxin-α (LT-α) have been associated with outcome in solid and hematologic malignancies. Within the TNF gene and the LT-α gene, polymorphisms have been identified at nucleotide positions -308 and +252, respectively. The variant alleles for TNF are designated TNF1 and TNF2, the ones for LT-α LT-α (10.5 kb) and LT-α (5.5 kb). Of interest, TNF2 and LT-α (5.5 kb) were shown to be associated with higher TNF and LT-α plasma levels than their counterparts. In the present study, we investigated the associations of the above mentioned polymorphisms with risk of relapse in childhood acute lymphoblastic leukemia (ALL) treated according to Berlin-Frankfurt-Münster (BFM) protocols. SN - 2052-1839 UR - https://doi.org/10.1186/1471-2326-1-2 DO - 10.1186/1471-2326-1-2 ID - Stanulla2001 ER -